Prosecutors mentioned there was inadequate proof towards a fifth agent.
Individuals named will now have 20 days to respond, and any demo will most likely be in absentia.
The Cambridge College university student were investigating impartial trade unions - a sensitive concern in Egypt.
Italian prosecutors named the four suspects - now established to generally be charged - as Gen Tareq Sabir, Col Ather Kamal, Maj Magdi Sharif and Col Hisham Helmy.
There was no fast response from Egypt towards the Italian allegations.
Egyptian authorities have previously denied that any in their officials had been linked to Regeni's kidnap and murder. They have instructed numerous other explanations - which include that he was the target of the theft by a legal gang.
And on one December they reported they were being "quickly closing" the investigation to the murder, Using the killer "nonetheless unknown".
Regeni went lacking in Cairo in January 2016 and his mutilated and naked overall body was present in a ditch in the vicinity of Cairo 9 days later on.
The murder brought on a diplomatic row between The 2 international locations, with Italian prosecutors accusing Egyptian officials of seeking to mislead the investigation.
"We have obtained unequivocal and considerable proof," Rome chief prosecutor Michele Prestipino instructed a news convention on Thursday.
"For Giulio's murder there is just gonna be 1 demo, and it will be held in Italy."
he BBC's Rome correspondent Mark Lowen states any demo will throw cerco uomo per amicizia a spotlight on Egypt's dire human legal rights record. Egypt's Commission for Legal rights and Freedoms says in excess of 2,seven hundred people have been "forcibly disappeared" considering the fact that 2015.
And YOURURL.com it could prompt questions on a rapprochement with Italy's current federal government, which lately accepted enormous arms profits to Cairo, our correspondent claims.
What happened to Giulio Regeni?
The PhD pupil disappeared over a investigate vacation on twenty five January 2016 - the fifth anniversary of the start in the rebellion versus former President Hosni Mubarak, that means there was a hefty police existence in Cairo.
An Italian submit-mortem evaluation located that Regeni had been tortured "in levels" amongst 25 January along with the working day of his Dying.
His physique sustained injuries that showed he was overwhelmed with "kicks, fists, sticks and clubs", Which he died from a broken neck, prosecutors reported.
Egypt has denied that Regeni died in custody Though officials have admitted that protection solutions were monitoring him.
Egyptian investigators have Earlier prompt that Regeni was murdered by a 5-robust criminal gang - and that each one of them were being then killed in a very shootout. Italian officials have branded the idea "implausible".
Italian prosecutor Sergio Colaiocco informed a parliamentary Fee that Egyptian officials experienced created "pretend tales... to toss from the investigation".
Other solutions put forward by Egyptian investigators had been that Regeni died in a car or truck incident or a gay criminal offense of enthusiasm.
His system was uncovered on three February in a very ditch because of the aspect of a street. His mother told the Italian parliament in 2018 that her son's system was so disfigured that she was only in a position to identify him because of the idea of his nose.